Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

The Arizona Cardinals suffered another blowout loss. On Sunday at State Farm Stadium, they gave up a 98-yard kickoff return to start the game and fell behind 14-0. Jacoby Brissett set an NFL record with 47 pass completions, but he threw two interceptions, and the 49ers dominated, cruising to a 41-22 victory.

The San Francisco 49ers face their division rivals, the Arizona Cardinals, at State Farm Stadium in Glendale, Arizona on Sunday, Nov. 16 at 1:05 p.m. PDT. 49ers as NFC's No. 1 seed? Don't laugh — the path is clear Contender or pretender: Could Bears ...

Christian McCaffrey and the San Francisco 49ers (6-4) will visit Trey McBride and the Arizona Cardinals (3-6) on Sunday at 4:05 p.m. ET, in a matchup between a pair of the brightest stars in the NFL. The 49ers are compiling 356.2 yards per game on offense ...

The San Francisco 49ers will take on the Arizona Cardinals on Sunday afternoon at State Farm Stadium in a division matchup that could result in Kyle Shanahan's squad sweeping the season series against Jonathan Gannon's. On Saturday, San Francisco announced ...