This idea of splitting the anti-CD3 paratope ensures that each of the two drug components is completely inactive until both bind simultaneously to target antigens on the same tumor cell.

Antibodies are best known for their ability to latch onto and neutralize bacteria, viruses and other pathogens. But these ...

we have improved the resolution of antigen arrays down to the epitope level. In this analysis, three distinct patterns of antibody reactivity were identified: (i) peptides that were differentially ...