B cell receptor (BCR) tonic signalling in immature B cells promotes the positive selection of cells with unligated receptors through a phosphoinositide 3-kinase (PI3K)-dependent pathway ...

and pre-B cell receptor (BCR) signalling. Continual BCR signalling is required for the propagation of many B cell malignancies. The transcription factor forkhead box protein O1 (FOXO1) and the B ...

In the study, "Disease diagnostics using machine learning of B cell and T cell receptor sequences," published in Science, researchers analyzed BCR heavy chain and TCR beta chain sequences from 593 ...

switches from an inhibitory role to an activating role when B cell receptor (BCR) signaling is compromised due to a genetic defect that causes an immune disorder. Contact between BCRs and foreign ...

Antigenic stimulation mediated by the B-cell receptor (BCR) regulates survival, proliferation and migration processes in B-CLL, thus suggesting a prominent role in B-CLL pathogenesis and progression.

Cellecta, Inc. today announced the launch of the DriverMap™ Adaptive Immune Receptor (AIR) TCR and BCR kits, a family of multiplex-PCR, NGS-based assays that enable profiling of up to all seven T-cell ...

On this landscape, the IgM-class B cell antigen receptors (IgM-BCR) accumulate in specific areas. The precision of the receptors’ localization and their clustering into larger units likely ...

It shows a high degree of specificity for BCR-ABL, the receptor for platelet-derived growth factor, and c-kit tyrosine kinases. 11 STI571 causes arrest of growth or apoptosis in hematopoietic ...

Imatinib mesylate (Gleevec, Novartis) is an inhibitor of multiple tyrosine kinases, including ABL, BCR-ABL, platelet-derived growth factor receptor (PDGFR), and c-kit. By preventing the ...

Leveraging receptor sequence data could allow simultaneous ... and 220 healthy controls. Paired BCR and TCR data were available for 542 individuals. Mal-ID correctly classified immune status ...

Over the past decade, several features of the B-cell receptor (BCR) complex have emerged as major markers for prognostic classification of B-cell chronic lymphocytic leukemia (B-CLL). In ...