Nature

BRCA1 and BRCA2 mutations in Scotland and Northern Ireland

Worldwide variation in the distribution of BRCA1 and BRCA2 mutations is well recognised (Szabo and King, 1997). In several populations or ethnic groups, distinctive founder mutations form a sufficient ...
Fred Hutch

BRCA1/2: Why men should be screened for the “breast cancer gene”

They are genes commonly associated with breast cancer in women, but in fact men who carry certain mutations in their BRCA1 or BRCA2 genes are at higher risk of developing certain types of cancer ...
Nature

Clinical outcome of prophylactic oophorectomy in BRCA1/BRCA2 mutation carriers and events during follow-up

A retrospective study was performed to assess the histopathologic findings in high-risk women undergoing bilateral prophylactic (salpingo)-oophorectomy. The medical files of BRCA1 or BRCA2 mutation ...
Australian Broadcasting Corporation

BRCA1, BRCA2 study provides new clarity on breast cancer risk for carriers of gene mutations

A new study has provided a better understanding of the risk of breast cancer for carriers of the BRCA1 and BRCA2 gene mutation, which points to the need for early identification and lifelong ...
Healio

Researchers define cancer risk in BRCA1/BRCA2 carriers

Please provide your email address to receive an email when new articles are posted on . Annualized incidence and cumulative risks for breast, ovarian and contralateral breast cancer served as the main ...

Women with BRCA mutations may be suffering unnecessarily due to ‘misinformation’ about treatment: study

However, many women with BRCA mutations perceive MHT as unsafe, due to concerns about their already elevated breast cancer ...
CURE

HRT Use Does Not Raise Breast Cancer Risk in BRCA Carriers

The use of hormone replacement therapy (HRT) does not have an adverse effect on breast cancer risk according to results from ...
Medscape

Differing Clinical Impact of BRCA1 and BRCA2 Mutations in Serous Ovarian Cancer

Chetrit et al. (2008) Case–control; Ashkenazi Jewish; BRCA1/2 213 (BRCA1: 159; BRCA2: 54) 392 Median survival (months): BRCA1/2, 53.7; noncarriers, 37.9 5-year ...
CURE

SHARON Trial Offers a Potential Approach for Advanced Pancreatic Cancer

The SHARON trial is a phase 1 study testing a new treatment called GO-4 for patients with advanced pancreatic cancer who have ...
Los Angeles Times

Ovarian cancer: BRCA2 mutation associated with improved survival

Having mutations in the BRCA1 or BRCA2 genes lead to a higher risk of breast and ovarian cancers in women, but the mutations don’t affect health outcomes in exactly the same way. A team led by ...

Menopausal hormone therapy may not pose breast cancer risk for women with BRCA mutations, analysis suggests

Using menopausal hormone therapy (MHT) was not associated with an increased risk of breast cancer in women with inherited ...
MedPage Today

Hormonal Contraception Linked to Increased Breast Cancer Risk in BRCA1 Carriers

Carriers of the BRCA1 cancer gene had a significantly increased risk of breast cancer if they used hormonal contraception (HC), pooled cohort data showed. Breast cancer risk increased by 29% in BRCA1 ...