Under conditions of low unfolded protein stress, the lumenal domains of PERK and IRE1 are in complex with the endoplasmic reticulum chaperone BiP, whose binding correlates with the inactive state ...

HYPE-mediated AMPylation of BiP is critical for maintaining proteostasis in the endoplasmic reticulum and mounting a unfolded protein response in times of proteostatic imbalance. Thus, manipulating ...

Scientists apply principles of math and physics to unravel the mystery of how the endoplasmic reticulum, an organelle vital ...

Moreover, recent experiments suggest that endoplasmic reticulum (ER ... levels of the chaperones BiP and GRP94 were increased, and apoptosis was dysregulated in the growth plates of affected ...

The endoplasmic reticulum (ER) is the primary site of protein ... Additionally, recombinant BiP, an ER-resident chaperone, has demonstrated promise in enhancing gut barrier integrity and reducing ...