Under conditions of low unfolded protein stress, the lumenal domains of PERK and IRE1 are in complex with the endoplasmic reticulum chaperone BiP, whose binding correlates with the inactive state ...

The endoplasmic reticulum (ER) is the primary site of protein ... Additionally, recombinant BiP, an ER-resident chaperone, ...

HYPE-mediated AMPylation of BiP is critical for maintaining proteostasis in the endoplasmic reticulum and mounting a unfolded protein response in times of proteostatic imbalance. Thus, manipulating ...

Moreover, recent experiments suggest that endoplasmic reticulum (ER ... levels of the chaperones BiP and GRP94 were increased, and apoptosis was dysregulated in the growth plates of affected ...

Nucleotide exchange factor SIL1 is an important regulator of endoplasmic reticulum function that might have a specific ... Diminished Ost3-dependent N-glycosylation of the BiP nucleotide exchange ...

Dynamic remodeling of the endomembrane system is a core biological process essential for maintaining cellular compartmentalization and homeostasis. Proteins enriched in intrinsically disordered ...