For years, Yale researchers David Breslow and Mustafa Khokha have worked together with a similar challenge in their ...

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Ulrike Künzel, Associate Director in the Functional Genomics department at AstraZeneca, about the application of arrayed ...

An artistic rendering of CRISPR-enhanced T-cells attacking a tumor. Research has shown that the gene-editing system CRISPR can modulate T cell behavior to make them better cancer killers without ...

The brain is often referred to as a "black box" - one that's difficult to peer inside and determine what's happening at any given moment. This is part of the reason why it's difficult to understand ...

RNAi (RNA interference) and CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) screening are two powerful techniques at the forefront of functional genomics research. Both techniques ...

Drug developers are consistently aiming to enhance clinical relevance in drug discovery. CRISPR has emerged as a versatile tool to accelerate the entire drug discovery process, with arrayed CRISPR ...

The study combines a deep learning model with CRISPR screens to control the expression of human genes in different ways -- such as flicking a light switch to shut them off completely or by using a ...

Using a new CRISPR-based methodology for modulating DNA structure to enact epigenetic control over specific genes, a team of researchers has identified a “master regulator” gene capable of improving T ...

CRISPR-based screening identifies H2AZ1 as a driver of cellular senescence. (A) Schematic of CRISPR-based loss-of-function (LOF) screening for histone variant-associated genes (HVRGs) to identify ...

This figure shows the structure of PTGES3. The research team made the association after creating a fluorescent tag that tracks androgen receptor levels in real time. The androgen receptor is a hormone ...