We now know that the substance originally termed slow-reacting substance of anaphylaxis was composed of three cysteinyl leukotrienes that act in the inflammatory response via receptors on smooth ...

More information: Mengting Jiang et al, Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4, Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.

AM PEF: Weakly mean morning peak expiratory flow; FEV1: Forced expiratory volume in 1 s; FVC: Forced vital capacity; LTRA: Leukotriene-receptor antagonist. Chronic overproduction of cysteinyl ...