When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...

Failures in DNA replication can lead to cancer, birth defects or other harm Video shows single pieces of double-helix DNA being copied Single-molecule view gives new insights into this process ...

Many human diseases have been linked to dysfunction in mitochondria, organelles in every cell that are responsible for generating energy, and which have their own set of DNA that they maintain ...

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

The replication of DNA is initiated at particular sites on the genome called replication origins (ROs). Understanding the constraints that regulate the distribution of ROs across different organisms ...

Replication protein A (RPA), a highly conserved single-stranded DNA-binding protein in eukaryotes, is a stable complex comprising three subunits termed RPA1, RPA2, and RPA3. RPA is required for ...

The ribosome is a highly complex and abundant protein-RNA machinery responsible for translating mRNA into protein. It is largely composed of specialized RNA known as ribosomal RNA (rRNA) as well as ...