For Week 17 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 17 NFL schedule here. After analyzing every game in Week 17, the AI says the Steelers (-3, 33.5), who have won three in a row, cover comfortably against the Browns.

Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on Dec. 22. Who will win?

Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

The Indianapolis Colts will look to snap a four-game losing streak when they battle the San Francisco 49ers on Monday Night Football. San Francisco is coming off a 37-24 win over the Tennessee Titans on Sunday,

One of the Mountain West’s hottest teams has a chance to knock off a struggling Big Ten team in this year’s Rate Bowl. New Mexico will face off against Minnesot

Get the best Washington State vs. Utah State predictions ahead of Monday's matchup in Boise. Free college football picks for December 22.

SportsLine's model simulated Indianapolis vs. San Francisco on 'MNF' 10,000 times and reveals its NFL picks today

NFL Week 16 has arrived and we asked USA TODAY Sports' staff for their top bets for the entire NFL slate. Here are their picks and predictions.

Preview the Georgia Bulldogs' college football Sugar Bowl matchup with Ole Miss, including betting odds, tips, trends, and game information.

Week 17 is the championship matchup in a vast majority of Fantasy football leagues, so it's the biggest week for Fantasy lineup decisions of the year for those who have made it thus far. In 2024, the players who had starred all year also showed up in the penultimate week as Joe Burrow,

The Denver Broncos and Kansas City Chiefs clash Christmas night. Kickoff for Thursday Night Football is at 8:15 p.m. ET in Kansas City, Missouri.