LAKE ST. LOUIS, Mo. – Westbound lanes on Interstate 64 in Lake St. Louis were closed Thursday afternoon due to a car fire. According to the Missouri Department of Transportation, the incident ...

A busy exit on Interstate 64 giving you access to Midtown and the Central West End could be back open in a few weeks.

ST. LOUIS — The Missouri Department of Transportation is sharing its latest plans for major changes to Interstate 64 in St. Louis, including replacing or rehabbing bridges and changing traffic ...

ST. LOUIS — A motorcyclist was ejected off Interstate 64 and fell to his death early Saturday near downtown St. Louis. He has been identified as 32-year-old Barry Light of Pevely, Missouri.

Provided A 29-year-old man lost his life in a fiery, one-car crash on an East St. Louis interstate ... on the southbound Interstate 55 exit ramp to Interstate 64 when the crash occurred at 6: ...