as well as hemizygous cells with both a knockin and a knockout mutation. These models can be delivered in as little as 13 weeks, with the timelines dependent on the number of alleles that need to ...

One involves studying the effect of a 'candidate' gene on a phenotype; for example, using transgenesis or homologous recombination (creating 'knockout' or 'knockin' mice). The other entails using ...

We provide transgene expression in mammalian cell lines using lentiviral and retroviral transduction and gene knockout and knockin using CRISPR/Cas9 technologies. 1. STABLE CELL LINE GENERATION ...

including the generation of a Setd2-CD knockin mouse model through homologous recombination technology, followed by a comparative analysis with the existing Setd2 knockout model. The Setd2-CD mice ...