The current 5-year funding period of KOMP2 is creating and characterizing knockout mice for 1,227 genes. All mouse model production and phenotyping data generated by the BCM KOMP2 are available ...

In these cases, a knockout mouse is referred to as a mouse model of that form of human disease. The first step in making a knockout mouse is identifying the region of the gene that will be deleted.

In this study, a mouse model with a knockout of the mitochondrial tRNA modification enzyme (Mto1) exhibited defective ...

Knockout technology is extraordinarily powerful ... Peters, L. L. et al. The mouse as a model for human biology: a resource guide for complex trait analysis. Nature Rev. Genet.

Rationale.The central nervous system (CNS) is the most complex structure of the animal organism both in terms of its development and function. CNS phenotyping requires special skills and equipment, ...