The current 5-year funding period of KOMP2 is creating and characterizing knockout mice for 1,227 genes. All mouse model production and phenotyping data generated by the BCM KOMP2 are available ...

In these cases, a knockout mouse is referred to as a mouse model of that form of human disease. The first step in making a knockout mouse is identifying the region of the gene that will be deleted.

The “R2G2” (B6;129-Rag2tm1FwaIL2rgtm1Rsky/DwlHsd) knockout mouse is the latest advancement to provide an alternative option in the highly immunodeficient mouse model category for oncology, immunology ...

The Cambridge knockout mouse (Cftr tm1Cam) line: Useful for studies of nonsense ... CF null (CFTR-/-) rat: The first CF rat model, CFTRtm1sage, was designed in collaboration with SAGE (now Envigo) in ...

In this study, a mouse model with a knockout of the mitochondrial tRNA modification enzyme (Mto1) exhibited defective mitochondrial protein synthesis, revealing a previously unknown molecular ...

We focus on the mouse as a model organism or the development of new technologies ... its hosting of its Center for Precision Medicine Models, and participation in the Knockout Mouse Project. The ...

A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...

This work will be led by my graduate student, Douglas Guzior. Finally, we plan to use a new knockout mouse model we have established here at Michigan State University to further explore the ...