Diablo 4 Vessel of Hatred is re-introducing Runes to the Diablo experience. If you don’t know what they are, runes are socketable items that, when paired together appropriately, form a Rune Word. Rune ...

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To begin your hunt for the Runes Book, reach the area called Fitzroy’s Gorge. This area is unlocked after defeating The Hushed Saint, the first of the five major bosses, in the Forsaken Fen area.