Low thyroid function (hypothyroidism) can lead to dry or mottled skin but also cause a life-threatening coma called myxedema.

6 Studies of the metabolism of intravenously administered D-xylose were performed in 8 normal subjects, 5 with myxedema and 6 with thyrotoxicosis. D-xylose was dissolved in pyrogen-free water ...

also known as primary myxedema), and ablation of the thyroid gland (surgical or after [131] I therapy). Secondary hypothyroidism as a consequence of pituitary or hypothalamic disease is rare ...