Orexins are neurotransmitters, which are chemicals in your brain that send messages from one neuron (a nerve cell) to another. When you’re awake, those neurons send out orexins. The orexins then ...

Japanese drugmaker Takeda has suspended dosing in phase 2 trials of its orexin agonist TAK-994, saying it had encountered a "safety signal" in the study. The future of the programme seems to be in ...

Idorsia has become the first drugmaker in the EU to claim approval for a drug for chronic insomnia in the dual orexin receptor antagonist class, ahead of rival drugs from Merck & Co and Eisai.