DEAD-box RNA helicases (DBRHs) modulate RNA secondary structure, allowing RNA molecules to adopt the conformations required for interaction with their target proteins. RH50 is a chloroplast-located ...

RNA helicases are a ubiquitous and evolutionarily conserved group of enzymes that play a central role in RNA metabolism. In plants, these proteins participate in processes ranging from pre‐mRNA ...

In a recent study published in the PNAS Journal, researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication. They characterized the ...

Both UAP56 and URH49, which form essential complexes for mRNA export, evolved from a common ancestral gene. However, the distinct roles that these complexes play, as well as the structural differences ...

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections - and, alas, extraordinarily difficult to target with drugs. Now, new ...

Researchers have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, ...

March 21, 2012 (San Diego, California) — A novel helicase-primase inhibitor with antiviral activity against the varicella zoster virus might provide an alternative as potent as current treatments for ...