Neurons crowded with distended endosomes are a hallmark of Alzheimer’s disease, but does this malfunction drive the neurodegenerative cascade? A new transgenic mouse, described last November 24 in ...

The small GTPase RAB5 was recently shown to have a role in mitosis in mammalian cells, and this study demonstrates that this function is conserved in Drosophila melanogaster. The authors find that ...

Writing in the April 11 issue of The Journal of Clinical Investigation, researchers at University of California, San Diego School of Medicine say abnormalities in a protein that helps transport and ...

Abnormalities in a protein that helps transport and sort materials inside cells are linked to axonal dysfunction and degeneration of neurons in Alzheimer's disease and Down syndrome, report ...

This is a preview. Log in through your library . Abstract Generation and turnover of phosphoinositides (PIs) must be coordinated in a spatial- and temporal-restricted manner. The small GTPase Rab5 ...

Down syndrome (DS) is the most prevalent genetic cause of Alzheimer’s disease (AD). Previous evidence suggests that increased dosage of the amyloid precursor protein (APP) gene plays a crucial role in ...

Cells have a fascinating feature to neatly organize their interior by using tiny protein machines called molecular motors that generate directed movements. Most of them use a common type of fuel, a ...

A new study shows inhibiting the kinase p38α using the small molecule drug neflamapimod, could potentially improve cognitive and motor function in patients with neurodegenerative diseases that affect ...