The term "knockout mouse" may at first conjure images of a mouse boxing champion or beauty queen. However, geneticists use the term to refer to a mouse that has been genetically engineered such ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

The Cambridge knockout mouse (Cftr tm1Cam) line: Useful for studies of nonsense ... CF null (CFTR-/-) rat: The first CF rat model, CFTRtm1sage, was designed in collaboration with SAGE (now Envigo) in ...

At first glance it seems that the use of transgenic ... which the embryonic stem cells were generated, a heterozygous knockout mouse on a homogeneous background is created and homozygous knockout ...

To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...