The cellular life cycle, also called the cell cycle, includes many processes necessary for successful self-replication. Beyond carrying out the tasks of routine metabolism, the cell must duplicate ...

How is a normal cell transformed into a cancerous cell? The proteins involved in cell division events no longer appropriately drive progression from one cell cycle stage to the next. Cells that ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.