Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer ...

The team is optimizing the cancer genome analysis system to integrate it into CRC diagnosis and tailor treatments based on ...

The APC gene was discovered by Kimmel Cancer Center researchers in 1991, and mutations in APC occur in over 90% of all ...

Researchers used mutational analysis to identify gene mutations that may drive carcinogenesis in colorectal tumors with high ...

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer ...

Genetic sequencing revealed a high prevalence of mutations to the organoids’ previously functional APC allele. This is known in cancer biology as loss of heterozygosity, and is reported in nearly 80 ...

Figure 2: Human APC and CTNNB1 mutations are associated with carcinogenesis. Figure 3: Cancer therapeutics that target components of the canonical Wnt pathway. Recent studies suggest that so ...

Once a specific genetic mutation has been found in the proband, however, other family members can be tested for the same mutation with virtually 100% accuracy. [1] ...