After VERVE-102 showed the ability to lower LDL-C and PCSK9 in the Heart-2 trial, the firm said it will advance the therapy to a Phase II study later this year.

Verve shares Phase 1b results of VERVE-102, showing dose-dependent LDL-C reductions and strong safety in patients with HeFH ...

DNA is often seen as the blueprint of life—carrying the code to govern the development and traits of an organism—but “there are things beyond the DNA sequence,” says Xiaoqi Feng, a plant geneticist at ...

Mutations can occur when adenine is altered or mismatched with other bases. For example, the deamination of adenine can lead to the formation of hypoxanthine, which can pair with cytosine instead of ...

New precision genome editing technologies are transforming the therapeutic landscape for patients with certain cancers and ...

Now, researchers at Harvard University have designed a new class of adenine base editors (ABEs) that can efficiently turn A-T into G-C, opening up the majority of pathogenic point mutations for ...

In the double helix structure of DNA, thymine forms a base pair with adenine through two hydrogen bonds. This specific pairing is known as complementary base pairing and is essential for the stability ...

Other combinations of the atoms form the four bases: thymine (T), adenine (A), cytosine (C), and guanine (G). These bases are the rungs of the DNA ladder. (It takes two bases to form a rung -- one ...

Adenine base editing corrects G542X mutation in CFTR in patient organoid models March 13, 2025 CF is caused by loss-of-function mutations in the CF transmembrane conductance regulator ( CFTR ) that ...