More specifically, we found that these proteins act at DNA sequences that contain a large number of adenine and thymine bases, which are particularly prone to forming complex structures ...

This work elucidates the mechanism of TALEDs, a mitochondrial adenine base editor, and develops enhanced tools (eTALED6s) with significantly improved efficiency and precision, offering new avenues ...

This important study provides solid evidence for new insights into the role of Type-1 nNOS interneurons in driving neuronal network activity and controlling vascular network dynamics in awake, ...

Systematic evaluation of near-PAMless base editors enables a robust deep learning model for predicting editing outcomes, facilitating broader and more precise targeting of disease-associated ...

Change orientation to land scape to view the price table ...

Contributed by Jian-Kang Zhu; received November 8, 2024; accepted March 7, 2025; reviewed by Cao Xu and Ramin Yadegari ...