You have full access to this article via your institution. APC is a ubiquitiously expressed, large scaffold protein with multiple binding partners and functions. It is the major negative regulator ...

You have full access to this article via your institution. To prove the interaction between the APC protein and PTP-BL also in lysates of mammalian cells, we constructed APC/GST-fusion proteins ...

Using several microdevices—filters, channels, protein substrates and layers ... The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration, Science Advances (2022).

UNC scientists led by Eva Anton, PhD, professor of cell biology and physiology in the UNC School of Medicine, have shown how the deletion of the protein APC in progenitor cells leads to massive ...

TAMPA, Fla. (Jan. 31, 2022) ---A University of South Florida Health (USF Health) preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients ...

"Our work reveals new information about how the APC protein functions to prevent colon tumor formation. This new information opens new possibilities treating and preventing colon cancer.

The adenomatous polyposis coli (APC) gene mediates the production of APC protein. The APC protein regulates cell growth by preventing cells from dividing too fast or in a disorderly way.

In other words, if the colorectal cancer is due to APC mutations, it is advisable to inhibit the mTORC1, and if it is associated to intestinal inflammation, this protein should be activated.

Additionally, they found that many of the changes affect molecular pathways consistent with the function of the APC protein as a tumor suppressor, including how the cell moves, interacts with ...

APC) (0E8.F) is pleased to announce that its new fusion protein, APC 103, exhibited enhanced activity over the parent protein in retarding tumor growth in animal studies, comparable to APC 101 ...