Lysine acetoacetylation (Kacac) is a recently discovered histone post-translational modification (PTM ... A detailed explanation is needed for selecting H2B (1-26) K25 sites over other acetylation ...

School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China ...

Our group retains an interest in the areas of structure-function studies of RNA interference mediated by siRNA pathway, and on post-translation histone and DNA modifications impacting on epigenetic ...

Two closely related Arabidopsis RPD3-type histone deacetylases HDA19 and HDA6, exhibit functional divergence, yet the molecular mechanisms underlying this divergence remain largely unclear. This study ...

The study unveils epigenetic modifiers involved in placing this mark, including key histone acetyltransferases such as p300, and concomitant HDACs, which remove the mark. Proteomic and bioinformatics ...

Non-histone acetylation also plays a key role in inflammatory regulation. SIRT1 deacetylates the p65 subunit of NF-κB, suppressing its activity and reducing the production of inflammatory factors, ...

The last few years have provided us with a new level of understanding of how chromosomes are replicated, segregated and read - and how their 3D organisation influences expression of individual genes ...