These changes were linked to pathways involving cell differentiation, actin filament organization, and negative regulation of the MAPK cascade. Downregulated genes were often involved in the ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

Research on guinea pig embryos uncovers similarities to human embryogenesis, advancing understanding of preimplantation ...

Fibroblast growth factor (FGF) signaling elicits multiple downstream pathways, most notably the Ras/MAPK cascade facilitated by the adaptor protein Grb2. However, the mechanism by which Grb2 is ...

Combination treatment of QTX3544 with cetuximab significantly enhanced anti-tumor efficacy and elicited greater tumor regressions in pancreatic and colorectal KRAS G12V -mutant cell line-derived ...

It plays a vital role in activating or inhibiting pathways such as MAPK and PI3K/Akt, modulating apoptosis-related proteins like Bcl-2 and Bad, and promoting the NF-κB signaling cascade. Through these ...

In a recent paper published in Nature, researchers from the University of Michigan have discovered that simultaneously targeting PIKfyve and KRAS-MAPK can eliminate tumors in preclinical human and ...

The Company will present updated interim clinical data from its onging Phase 1 clinical trial of PAS-004 in patients with MAPK pathway driven advanced solid tumors. "We are pleased to present interim ...