Background: In patients with juvenile polyposis syndrome (JPS) the frequency of large genomic deletions in the SMAD4 and BMPR1A genes was unknown. Methods: Mutation and phenotype analysis was used in ...

Absence of Progression As Assessed by Response Evaluation Criteria in Solid Tumors Predicts Survival in Advanced GI Stromal Tumors Treated With Imatinib Mesylate: The Intergroup EORTC-ISG-AGITG Phase ...

In 1997, a Johns Hopkins research team found an inherited genetic mutation called APC I1307K. Adenomatous polyposis coli (APC) is a gene that suppresses tumor growth. If the APC gene is defective, it ...

Biodexa Pharmaceuticals PLC announced that the European Commission has granted Orphan Drug Designation for its drug eRapa, aimed at treating familial adenomatous polyposis (FAP), a hereditary ...

Its lead candidates -- including REC-4881 for familial adenomatous polyposis and REC-7735 for breast cancer -- have demonstrated promising early results. The company's AI-first approach enables ...

The table below is a review of notable updates that occurred in April 2025 for investigational products in development (not an inclusive list). Click on the status to view our full coverage.

Colon cancer is a type of cancer (abnormal cells growing uncontrollably) that begins in the large intestine. Irritable bowel syndrome (IBS) is a disorder in how the brain and gut communicate and ...

This includes familial adenomatous polyposis (FAP). There may also be a link with Lynch syndrome. But the evidence for this is less clear. There are many other conditions that cause these symptoms.

Background: The prevalence of duodenal carcinoma is much higher in familial adenomatous polyposis (FAP) than in the background population, and duodenal adenomatosis is found in most polyposis patients ...

breast cancer and rare diseases familial adenomatous polyposis and hypophosphatasia. At the end of March, Recursion had roughly $509 million in cash on hand compared to $603 million at the end of ...

allosteric MEK1/2 inhibitor in development for Familial Adenomatous Polyposis (FAP). These data were presented in a late-breaking oral presentation at Digestive Disease Week (DDW) 2025 in San ...