BMJ

Associations of occupational and leisure-time physical activity with all-cause mortality: an individual participant data meta-analysis

Objective Health effects of different physical activity domains (ie, during leisure time, work and transport) are generally considered positive. Using Active Worker consortium data, we assessed ...
Nature

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity

The AGC family of Ser/Thr protein kinases share remarkably similar mechanisms for regulating the activity of their kinase domains. These typically depend on (i) the phosphorylation of the ...
BMJ

Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose–response meta-analysis of large prospective studies

Objective To estimate the dose–response associations between non-occupational physical activity and several chronic disease and mortality outcomes in the general adult population. Design Systematic ...