A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

However, because so many mouse genes are similar to human genes, geneticists can generate knockout mice in which the mouse counterpart of a human gene of interest is deleted or disrupted.

To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...

Background and aims Metabolic dysfunction-associated steatotic liver disease (MASLD), is the most common form of chronic ...

Rationale.The central nervous system (CNS) is the most complex structure of the animal organism both in terms of its development and function. CNS phenotyping requires special skills and equipment, ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...