Introduction: Antibody maturation in the lymphoid follicle produces antibodies with improved binding ... (BCR)-derived HLA-DR epitopes present in memory antibody repertoires from seven healthy human ...

Indeed, it qualitatively appears that the intermediate 4-, 5-, and 6mer BOAS were the most immunogenic and this length may be sufficient to effectively engage and crosslink BCR for potent stimulation.

BCR cross-linking by the self-antigens initiates BCR editing, which rearranges the Ig light chain genes to substitute the self-reactive receptors with the non-self-reactive receptors. The B cells ...

Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AX, U.K. Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AX, U.K. ART-AI, Department of Computer ...

Follow this channel for updates and analysis on all aspects of the European Union's General Data Protection Regulation, a reform of EU's data protection rules that ...

Mapping an antibody’s epitope, where it binds a target ... proteins bind to their intended targets, such as antigens or immunogens. That binding process depends on many factors.

The emergent deep learning methods excel at learning antigen binding patterns from known TCRs but struggle with novel or sparsely represented antigens. However, binding specificity for unseen antigens ...

Methods: We used bulk BCR ... antigen-specific B cells followed by paired heavy and light chain gene amplification and sequencing, 2) barcoded antigen approaches like LIBRA-seq which leverage single ...