Department of Biochemistry, University of Otago, New Zealand, Institute of Cancer Therapeutics, University of Bradford, England, and the Departments of Pharmacology and Paediatrics, University of ...

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell's main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted energy ...

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell's main energy currency, ...

Edited by Montserrat Samso, Virginia Commonwealth University, Richmond, VA; received October 4, 2022; accepted March 14, 2023 by Editorial Board Member Nieng Yan All subtypes of IP3Rs (IP3R1–3) have ...

The endoplasmic reticulum (ER) is the site at which secreted proteins (such as the hormone insulin) and membrane-bound proteins are folded. ATP-dependent chaperones within the ER help proteins fold.

ER stress‐related biomarkers, including BiP, CHOP, XBP1s, and ATF4 ... 17 reported that inhibiting the protein kinase RNA‐like endoplasmic reticulum kinase (PERK)—eukaryotic Initiation Factor 2 alpha ...

Turning once again to the scientific tool of reading previous research, the team found WASF3 reported to be regulated by BiP (GRP78), an endoplasmic reticulum (ER) chaperone for protein quality ...

The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of ... we report that calcium selectively affects the dynamics of the abundant metazoan ER Hsp70 chaperone BiP, by enhancing ...

Figure 3 The mitochondria-associated endoplasmic reticulum (ER) membrane (MAM ... and ATF6α bind to binding immunoglobulin protein (BiP) and are sequestered as inactive forms. Under stress, however, ...

Find out more about how we test, analyze, and rate. Editor's note, June 11:An Amazfit Bip Lite and the second-gen Bip 2 are reportedly due out this year, though it's unclear which features those ...

Figure 2. Endoplasmic reticulum (ER) stress sensors, unfolded protein response (UPR) activation, and signaling pathways. Under physiological conditions, the expression levels of the main ER chaperone ...