Hydrolysis of the phosphodiester linkages in DNA is a notoriously difficult reaction. Deoxyribozymes that use Zn 2+ and Mn 2+ ions to accelerate this reaction by a factor of one hundred million ...

Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85748 Garching, Germany Institute for Advanced Study, Technical University of Munich, Lichtenbergstrasse 2a, 85748 ...