Additionally, certain tumor antigens, or molecules that immune cells recognize as threats, disappeared from the cancer cells. This may have allowed the tumors to escape immune detection.

Epitope mapping is a cornerstone of antibody development, informing everything from IP strategy to candidate selection. Traditionally, this requires expensive, time-consuming lab work using scarce ...

These therapies involve programming the T-cell receptor (TCR) of T cells to recognize a specific peptide, or antigen, found on tumor cells. There are many efforts underway to identify the most ...

A phase 1 trial of umbilical cord blood–derived tumor-reactive PD-L1+ natural killer cells engineered to express soluble IL-15 (TRACK-NK) in patients with non–small-cell lung cancer (NSCLC) refractory ...

This valuable manuscript aims to delineate the epitope specificity in a panel of anti-amyloid-beta antibodies, including some with clinical relevance. The experiments were rigorously conducted, ...

qBureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, Japan rCenter for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan ...

Furthermore, it integrates data on antibody developability and antigen-drug target relationships, making it valuable for assisting new antibody therapies development. Notably, the database includes ...