The study discussed herein aims to demonstrate the efficacy of antigen-specific immunotherapies involving the conjugation of disease causing autoantigen, PLP 139–151, and a potent immunosuppressant, ...

Find more information on the Altmetric Attention Score and how the score is calculated. Antibody orientation and its antigen binding efficiency at interface are of particular interest in many ...

Epitope mapping is a cornerstone of antibody development, informing everything from IP strategy to candidate selection. Traditionally, this requires expensive, time-consuming lab work using scarce ...

qBureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, Japan rCenter for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan ...

This valuable manuscript aims to delineate the epitope specificity in a panel of anti-amyloid-beta antibodies, including some with clinical relevance. The experiments were rigorously conducted, ...

Furthermore, it integrates data on antibody developability and antigen-drug target relationships, making it valuable for assisting new antibody therapies development. Notably, the database includes ...

Additionally, certain tumor antigens, or molecules that immune cells recognize as threats, disappeared from the cancer cells. This may have allowed the tumors to escape immune detection.

Results: Among the 27 reviews, traditional machine learning approaches—random forests, support vector machines, gradient boosting, and logistic regression—dominated tasks from antigen discovery and ...