The first knockout mice were created in 1988, but the mice created so far only cover about a quarter of the mouse genome. Alongside other efforts in Asia, Europe and North America, the NIH knockout ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

In 1989 Mario R. Capecchi, Martin Evans and Oliver Smithies created the first knockout mouse, which led to them winning the Nobel Prize in Physiology or Medicine in 2007 for their work. Genome editing ...

Large collections of knockout organisms facilitate the ... Because all the SPDI genes are of human origin, we first identified each mouse ortholog using four criteria, namely reciprocal BLAST ...

Figure 1: Schematic of the ‘knockout-first’ conditional allele ... Our targeting pipeline is the major contributor to the international mouse knockout programmes that aim to generate lacZ ...

Those mechanisms include alterations in calcium and neuronal hyperactivity, which occur first in this mouse ... developed in the GluN3A knockout mouse in an age-dependent manner," Yu says.

(Getty Images) The University of California, Davis, has been awarded just over $12 million from the National Institutes of Health under the third and final five-year phase of the Knockout Mouse ...

The National Institutes of Health (NIH), announced the selection of the hospital's research institute for the Knockout Mouse Project (KOMP) on September 7, 2006. The $50 million initiative funded ...

Those mechanisms include alterations in calcium and neuronal hyperactivity, which occur first in this mouse ... developed in the GluN3A knockout mouse in an age-dependent manner," Yu says.