Reiner and his wife, Michele Singer Reiner, were found dead inside their Brentwood, Calif. home on Sunday afternoon at 78 and 68, respectively. The Los Angeles Police Department said at the time that their deaths were being investigated as a homicide, but that they had not identified a suspect and no one had been detained.

Meg Ryan addressed friend Rob Reiner and his wife Michele's tragic deaths. The actress, 64, wrote a moving tribute to her When Harry Met Sally director in a tearful post she shared on December 17.

The beloved star of Reiner’s 1989 romantic comedy leaned toward optimism: “I have to believe that their story will not end with this impossible tragedy, that some good may come, some awareness raised.

Meg Ryan has posted a poignant tribute to her 'When Harry Met Sally...' director, the late Rob Reiner, and his wife Michele Reiner.

Meg Ryan mourns 'When Harry Met Sally' director Rob Reiner and his wife, Michele Reiner, and reflects on their legacies

The award-winning director helmed classics from romcom When Harry Met Sally… to coming-of-age drama Stand By Me.