U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee, Virginia, Kentucky, and Indiana. The highway runs for 941 miles (1,514 km) from Fort Fisher, North Carolina, to US 20 in Michigan City, Indiana.

In the U.S. state of North Carolina, US 421 travels 328 miles (528 km) from its southern terminus at Fort Fisher to the Tennessee state line near the community of Zionville, North Carolina. US 421 traverses the state from east to west travelling from the coastal plains to Appalachian Mountains.

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U.S. Route 421 traverses approximately 328 miles (528 km) across North Carolina; from Fort Fisher, on a peninsula between the Atlantic and Cape Fear River, to the Tennessee state line near the community of Zionville.

U.S. Route 421 (US 421) in the U.S. state of Kentucky is a 250.536-mile-long (403.199 km) north–south United States highway that traverses twelve counties in the central and eastern parts of the state.

Oct 23, 2024 · In the U.S. state of North Carolina, US 421 travels 328 miles (528 km) from its southern terminus at Fort Fisher to the Tennessee state line near the community of Zionville, North Carolina. US 421 traverses the state from east to west travelling from the coastal plains to Appalachian Mountains.

U.S. Route 421 is a spur route of U.S. 21. It runs for 941 miles (1,514 km) from Michigan City, Indiana, at U.S. 20, to Fort Fisher in North Carolina.

Sep 23, 2024 · View a map showing this route. East: Greensboro, NC. *US 421 ended in Cumberland Gap for many years according to AASHO, and this was shown on many maps, including Virginia's official state highway maps.

U.S. Route 421 (US 421) enters Indiana from Kentucky, proceeding northwest to Indianapolis, joining Interstate 465, and then continuing northwest to Michigan City. US 421 winds through the southern part of Indiana as it runs from Madison, in the southeastern part of the state, to Indianapolis (the capital).

Heading toward Deep Gap on US 421, New River peeks out from the trees as the Blue Ridge Mountains come into the foreground for enviable views full of hardwood and mixed forest that in the chilly air of autumn burst with pops of red and yellow along the mountainsides.